Browsing NTNU Open by Author "Mendel, Mateusz"

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    • Essential roles of RNA cap-proximal ribose methylation in mammalian embryonic development and fertility 

      Dohnalkova, Michaela; Krasnykov, Kyrylo; Mendel, Mateusz; Li, Lingyun; Panasenko, Olesya; Fleury-Olela, Fabienne; Vågbø, Cathrine Broberg; Homolka, David; Pillai, Ramesh S. (Peer reviewed; Journal article, 2023)
      Eukaryotic RNA pol II transcripts are capped at the 5′ end by the methylated guanosine (m7G) moiety. In higher eukaryotes, CMTR1 and CMTR2 catalyze cap-proximal ribose methylations on the first (cap1) and second (cap2) ...

    • Splice site m<sup>6</sup>A methylation prevents binding of U2AF35 to inhibit RNA splicing 

      Mendel, Mateusz; Delaney, Kamila; Pandey, Radha Raman; Chen, Kuan-Ming; Wenda, Joanna M.; Vågbø, Cathrine Broberg; Steiner, Florian A.; Homolka, David; Pillai, Ramesh S. (Journal article; Peer reviewed, 2021)
      The N6-methyladenosine (m6A) RNA modification is used widely to alter the fate of mRNAs. Here we demonstrate that the C. elegans writer METT-10 (the ortholog of mouse METTL16) deposits an m6A mark on the 3′ splice site ...